import uuid
from datetime import date, timedelta
from typing import Sequence

from sqlalchemy import or_, select, update as sa_update
from sqlalchemy.ext.asyncio import AsyncSession

from app.models.ae import AdverseEvent
from app.models.site import Site
from app.models.subject import Subject
from app.schemas.ae import AECreate, AEUpdate


def _seriousness_rank(value: str | None) -> int | None:
    if not value:
        return None
    normalized = str(value).strip().upper()
    roman_map = {"I": 1, "II": 2, "III": 3, "IV": 4, "V": 5}
    legacy_map = {"SERIOUS": 5, "NON_SERIOUS": 1}
    return roman_map.get(normalized) or legacy_map.get(normalized)


def _calc_due_date(onset: date | None, seriousness: str) -> date | None:
    if onset is None:
        return None
    rank = _seriousness_rank(seriousness)
    delta = 1 if rank and rank >= 3 else 7
    return onset + timedelta(days=delta)


async def _validate_site_subject(db: AsyncSession, study_id: uuid.UUID, site_id: uuid.UUID | None, subject_id: uuid.UUID | None):
    if site_id:
        result = await db.execute(select(Site).where(Site.id == site_id))
        site = result.scalar_one_or_none()
        if not site or site.study_id != study_id:
            raise ValueError("分中心不属于当前项目")
        if not site.is_active:
            raise ValueError("中心已停用")
    if subject_id:
        result = await db.execute(select(Subject).where(Subject.id == subject_id))
        subj = result.scalar_one_or_none()
        if not subj or subj.study_id != study_id:
            raise ValueError("参与者不属于当前项目")
        result = await db.execute(select(Site).where(Site.id == subj.site_id))
        subj_site = result.scalar_one_or_none()
        if subj_site and not subj_site.is_active:
            raise ValueError("中心已停用")


async def create_ae(
    db: AsyncSession,
    study_id: uuid.UUID,
    ae_in: AECreate,
    *,
    created_by: uuid.UUID,
) -> AdverseEvent:
    await _validate_site_subject(db, study_id, ae_in.site_id, ae_in.subject_id)
    due_date = _calc_due_date(ae_in.onset_date, ae_in.seriousness)
    ae = AdverseEvent(
        study_id=study_id,
        site_id=ae_in.site_id,
        subject_id=ae_in.subject_id,
        visit_id=ae_in.visit_id,
        term=ae_in.term,
        onset_date=ae_in.onset_date,
        resolution_date=None,
        seriousness=ae_in.seriousness.value,
        severity=ae_in.seriousness.value,
        causality=ae_in.causality,
        action_taken=None,
        outcome=ae_in.outcome,
        reported_to_sponsor=False,
        is_sae=bool(ae_in.is_sae or ae_in.is_susar),
        is_susar=bool(ae_in.is_susar),
        report_due_date=due_date,
        status="NEW",
        description=ae_in.description,
        created_by=created_by,
    )
    db.add(ae)
    await db.commit()
    await db.refresh(ae)
    return ae


async def get_ae(db: AsyncSession, ae_id: uuid.UUID) -> AdverseEvent | None:
    result = await db.execute(select(AdverseEvent).where(AdverseEvent.id == ae_id))
    return result.scalar_one_or_none()


async def list_ae(
    db: AsyncSession,
    study_id: uuid.UUID,
    status: str | None = None,
    seriousness: str | None = None,
    site_id: uuid.UUID | None = None,
    subject_id: uuid.UUID | None = None,
    overdue: bool | None = None,
    site_ids: set[uuid.UUID] | None = None,
) -> Sequence[AdverseEvent]:
    stmt = select(AdverseEvent).where(AdverseEvent.study_id == study_id)
    if site_ids is not None:
        if not site_ids:
            return []
        subject_site_ids = select(Subject.id).where(Subject.site_id.in_(site_ids))
        stmt = stmt.where(
            or_(
                AdverseEvent.site_id.in_(site_ids),
                AdverseEvent.subject_id.in_(subject_site_ids),
            )
        )
    if status:
        stmt = stmt.where(AdverseEvent.status == status)
    if seriousness:
        stmt = stmt.where(AdverseEvent.seriousness == seriousness)
    if site_id:
        stmt = stmt.where(AdverseEvent.site_id == site_id)
    if subject_id:
        stmt = stmt.where(AdverseEvent.subject_id == subject_id)
    if overdue is True:
        stmt = stmt.where(AdverseEvent.report_due_date < date.today(), AdverseEvent.status != "CLOSED")
    if overdue is False:
        stmt = stmt.where((AdverseEvent.report_due_date >= date.today()) | (AdverseEvent.report_due_date.is_(None)) | (AdverseEvent.status == "CLOSED"))
    result = await db.execute(stmt)
    return result.scalars().all()


async def update_ae(db: AsyncSession, study_id: uuid.UUID, ae: AdverseEvent, ae_in: AEUpdate) -> AdverseEvent:
    update_data = ae_in.model_dump(exclude_unset=True)
    if "is_susar" in update_data and update_data["is_susar"]:
        update_data["is_sae"] = True
    if "is_sae" in update_data and update_data["is_sae"] is False:
        update_data["is_susar"] = False
    if "seriousness" in update_data:
        severity_value = update_data["seriousness"].value if hasattr(update_data["seriousness"], "value") else str(update_data["seriousness"])
        update_data["seriousness"] = severity_value
        update_data["severity"] = severity_value
    if "subject_id" in update_data:
        await _validate_site_subject(db, study_id, None, update_data["subject_id"])
    if "onset_date" in update_data or "seriousness" in update_data:
        onset = update_data.get("onset_date", ae.onset_date)
        seriousness = update_data.get("seriousness", ae.seriousness)
        update_data["report_due_date"] = _calc_due_date(onset, seriousness)
    if update_data:
        await db.execute(
            sa_update(AdverseEvent)
            .where(AdverseEvent.id == ae.id)
            .values(**update_data)
        )
        await db.commit()
    await db.refresh(ae)
    return ae


async def delete_ae(db: AsyncSession, ae: AdverseEvent) -> None:
    await db.delete(ae)
    await db.commit()