feat: refine subject visits and project workflows

Add early termination visit workflow with ordering, non-applicable visit handling, visit window display, and medication adherence support.

Extend monitoring visit issue template fields, site scoping, setup draft project info handling, login security UI, attachment behavior, and related tests/migrations.

backend/app/crud/subject.py

@@ -37,6 +37,11 @@ def _validate_subject_date_chain(
         raise ValueError("完成日期不能早于入组日期")
 
 
+def _validate_actual_medication_count(value: int | None) -> None:
+    if value is not None and value < 0:
+        raise ValueError("实际用药次数不能小于0")
+
+
 def _should_sync_visits(previous_baseline_date: date | None, next_baseline_date: date | None) -> bool:
     return next_baseline_date is not None and previous_baseline_date != next_baseline_date
 
@@ -132,6 +137,7 @@ async def update_subject(db: AsyncSession, subject: Subject, subject_in: Subject
         enrollment_date=next_enrollment_date,
         completion_date=next_completion_date,
     )
+    _validate_actual_medication_count(update_data.get("actual_medication_count", subject.actual_medication_count))
     if update_data:
         await db.execute(
             sa_update(Subject)