补齐业务路由与页面权限控制

backend/app/api/v1/aes.py

@@ -48,7 +48,7 @@ def _is_overdue(ae: AERead) -> bool:
     "/",
     response_model=AERead,
     status_code=status.HTTP_201_CREATED,
-    dependencies=[Depends(require_api_permission("risk_issues:create")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("subject_aes:create")), Depends(require_study_not_locked())],
 )
 async def create_ae(
     study_id: uuid.UUID,
@@ -86,20 +86,15 @@ async def create_ae(
     return data
 
 
-@router.get(
+async def _list_ae_records(
-    "/",
-    response_model=list[AERead],
-    dependencies=[Depends(require_api_permission("risk_issues:read"))],
-)
-async def list_ae(
     study_id: uuid.UUID,
-    status_filter: str | None = None,
+    status_filter: str | None,
-    seriousness: str | None = None,
+    seriousness: str | None,
-    site_id: uuid.UUID | None = None,
+    site_id: uuid.UUID | None,
-    subject_id: uuid.UUID | None = None,
+    subject_id: uuid.UUID | None,
-    overdue: bool | None = None,
+    overdue: bool | None,
-    db: AsyncSession = Depends(get_db_session),
+    db: AsyncSession,
-    current_user=Depends(get_current_user),
+    current_user,
 ) -> list[AERead]:
     await _ensure_study_exists(db, study_id)
     cra_scope = await get_cra_site_scope(db, study_id, current_user)
@@ -124,10 +119,64 @@ async def list_ae(
     return result
 
 
+@router.get(
+    "/summary",
+    response_model=list[AERead],
+    dependencies=[Depends(require_api_permission("subject_aes:list"))],
+)
+async def list_risk_issue_ae(
+    study_id: uuid.UUID,
+    status_filter: str | None = None,
+    seriousness: str | None = None,
+    site_id: uuid.UUID | None = None,
+    subject_id: uuid.UUID | None = None,
+    overdue: bool | None = None,
+    db: AsyncSession = Depends(get_db_session),
+    current_user=Depends(get_current_user),
+) -> list[AERead]:
+    return await _list_ae_records(
+        study_id,
+        status_filter,
+        seriousness,
+        site_id,
+        subject_id,
+        overdue,
+        db,
+        current_user,
+    )
+
+
+@router.get(
+    "/",
+    response_model=list[AERead],
+    dependencies=[Depends(require_api_permission("subject_aes:list"))],
+)
+async def list_ae(
+    study_id: uuid.UUID,
+    status_filter: str | None = None,
+    seriousness: str | None = None,
+    site_id: uuid.UUID | None = None,
+    subject_id: uuid.UUID | None = None,
+    overdue: bool | None = None,
+    db: AsyncSession = Depends(get_db_session),
+    current_user=Depends(get_current_user),
+) -> list[AERead]:
+    return await _list_ae_records(
+        study_id,
+        status_filter,
+        seriousness,
+        site_id,
+        subject_id,
+        overdue,
+        db,
+        current_user,
+    )
+
+
 @router.get(
     "/{ae_id}",
     response_model=AERead,
-    dependencies=[Depends(require_api_permission("risk_issues:read"))],
+    dependencies=[Depends(require_api_permission("subject_aes:read"))],
 )
 async def get_ae(
     study_id: uuid.UUID,
@@ -155,7 +204,7 @@ async def get_ae(
 @router.patch(
     "/{ae_id}",
     response_model=AERead,
-    dependencies=[Depends(require_api_permission("risk_issues:update")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("subject_aes:update")), Depends(require_study_not_locked())],
 )
 async def update_ae(
     study_id: uuid.UUID,
@@ -210,7 +259,7 @@ async def update_ae(
 @router.delete(
     "/{ae_id}",
     status_code=status.HTTP_204_NO_CONTENT,
-    dependencies=[Depends(require_api_permission("risk_issues:delete")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("subject_aes:delete")), Depends(require_study_not_locked())],
 )
 async def delete_ae(
     study_id: uuid.UUID,

backend/app/api/v1/dashboard.py

@@ -70,7 +70,7 @@ async def list_lost_visits(
 
 @router.get("/center-summary", response_model=list[CenterSummaryItem], dependencies=[
     Depends(require_study_member()),
-    Depends(require_api_permission("dashboard:read"))
+    Depends(require_api_permission("project_overview:read"))
 ])
 async def get_center_summary(
     study_id: uuid.UUID,
@@ -91,7 +91,7 @@ async def get_center_summary(
 
     stage_order = [
         ("institution_initiation_status", "机构立项"),
-        ("ethics_status", "伦理审批"),
+        ("ethics_status", "伦理记录"),
         ("contract_sign_status", "合同签署"),
         ("startup_status", "启动"),
         ("enrollment_status", "入组"),

backend/app/api/v1/members.py

@@ -19,9 +19,9 @@ PROJECT_ROLE_RANK = {
     "ADMIN": 100,
     "PM": 80,
     "PV": 50,
-    "MEDICAL_REVIEW": 50,
+    "QA": 50,
     "CRA": 40,
-    "IMP": 40,
+    "CTA": 40,
 }
 
 

backend/app/api/v1/monitoring_visit_issues.py

@@ -332,7 +332,7 @@ def _normalize_file_rows(filename: str, content: bytes) -> list[dict[str, object
 @router.get(
     "/issues",
     response_model=list[MonitoringVisitIssueRead],
-    dependencies=[Depends(require_api_permission("monitoring_audit:read"))],
+    dependencies=[Depends(require_api_permission("monitoring_issues:list"))],
 )
 async def list_monitoring_visit_issues(
     study_id: uuid.UUID,
@@ -382,7 +382,7 @@ async def list_monitoring_visit_issues(
     "/issues",
     response_model=MonitoringVisitIssueRead,
     status_code=status.HTTP_201_CREATED,
-    dependencies=[Depends(require_api_permission("monitoring_audit:create")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("monitoring_issues:create")), Depends(require_study_not_locked())],
 )
 async def create_monitoring_visit_issue(
     study_id: uuid.UUID,
@@ -421,7 +421,7 @@ async def create_monitoring_visit_issue(
 @router.get(
     "/issues/export",
     response_class=StreamingResponse,
-    dependencies=[Depends(require_api_permission("monitoring_audit:read"))],
+    dependencies=[Depends(require_api_permission("monitoring_issues:list"))],
 )
 async def export_monitoring_visit_issues(
     study_id: uuid.UUID,
@@ -553,7 +553,7 @@ async def export_monitoring_visit_issues(
 @router.get(
     "/issues/{issue_id}",
     response_model=MonitoringVisitIssueRead,
-    dependencies=[Depends(require_api_permission("monitoring_audit:read"))],
+    dependencies=[Depends(require_api_permission("monitoring_issues:read"))],
 )
 async def get_monitoring_visit_issue(
     study_id: uuid.UUID,
@@ -570,7 +570,7 @@ async def get_monitoring_visit_issue(
 @router.patch(
     "/issues/{issue_id}",
     response_model=MonitoringVisitIssueRead,
-    dependencies=[Depends(require_api_permission("monitoring_audit:update")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("monitoring_issues:update")), Depends(require_study_not_locked())],
 )
 async def update_monitoring_visit_issue(
     study_id: uuid.UUID,
@@ -625,7 +625,7 @@ async def update_monitoring_visit_issue(
 @router.delete(
     "/issues/{issue_id}",
     status_code=status.HTTP_204_NO_CONTENT,
-    dependencies=[Depends(require_api_permission("monitoring_audit:delete")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("monitoring_issues:delete")), Depends(require_study_not_locked())],
 )
 async def delete_monitoring_visit_issue(
     study_id: uuid.UUID,
@@ -655,7 +655,7 @@ async def delete_monitoring_visit_issue(
 @router.post(
     "/issues/import",
     response_model=MonitoringVisitIssueImportSummary,
-    dependencies=[Depends(require_api_permission("monitoring_audit:create")), Depends(require_study_not_locked())],
+    dependencies=[Depends(require_api_permission("monitoring_issues:create")), Depends(require_study_not_locked())],
 )
 async def import_monitoring_visit_issues(
     study_id: uuid.UUID,

backend/app/api/v1/overview.py

@@ -25,7 +25,7 @@ async def get_project_overview(
 
     返回项目各中心的进度情况，包括:
     - 机构立项状态
-    - 伦理审批状态
+    - 伦理记录状态
     - 合同签署状态
     - 启动会状态
     - 入组进度

backend/app/api/v1/router.py

@@ -1,6 +1,6 @@
 from fastapi import APIRouter
 
-from app.api.v1 import auth, users, admin_users, studies, sites, members, attachments, audit_logs, dashboard, subjects, visits, aes, finance_dashboard, finance_contracts, fees_contracts, fees_attachments, drug_shipments, material_equipments, project_milestones, startup, knowledge_notes, subject_histories, subject_pds, study_subject_pds, faq_categories, faqs, documents, overview, notifications, monitoring_visit_issues, api_permissions, permission_monitoring, permission_templates, system_permissions, study_active_roles
+from app.api.v1 import auth, users, admin_users, studies, sites, members, attachments, audit_logs, dashboard, subjects, visits, aes, finance_dashboard, fees_contracts, drug_shipments, material_equipments, project_milestones, startup, precautions, subject_histories, subject_pds, study_subject_pds, faq_categories, faqs, documents, etmf, overview, notifications, monitoring_visit_issues, api_permissions, permission_monitoring, permission_templates, system_permissions, study_active_roles
 
 
 api_router = APIRouter()
@@ -22,14 +22,12 @@ api_router.include_router(subjects.router, prefix="/studies/{study_id}/subjects"
 api_router.include_router(visits.router, prefix="/studies/{study_id}/subjects/{subject_id}/visits", tags=["visits"])
 api_router.include_router(aes.router, prefix="/studies/{study_id}/aes", tags=["aes"])
 api_router.include_router(finance_dashboard.router, prefix="/studies/{study_id}/finance", tags=["finance"])
-api_router.include_router(finance_contracts.router, prefix="/studies/{study_id}/finance", tags=["finance-contracts"])
 api_router.include_router(fees_contracts.router, prefix="/fees", tags=["fees-contracts"])
-api_router.include_router(fees_attachments.router, prefix="/fees", tags=["fees-attachments"])
 api_router.include_router(drug_shipments.router, prefix="/studies/{study_id}/drug", tags=["drug-shipments"])
 api_router.include_router(material_equipments.router, prefix="/studies/{study_id}/materials", tags=["material-equipments"])
 api_router.include_router(project_milestones.router, prefix="/studies/{study_id}/project", tags=["project-milestones"])
 api_router.include_router(startup.router, prefix="/studies/{study_id}/startup", tags=["startup"])
-api_router.include_router(knowledge_notes.router, prefix="/studies/{study_id}/knowledge", tags=["knowledge"])
+api_router.include_router(precautions.router, prefix="/studies/{study_id}/shared-library", tags=["precautions"])
 api_router.include_router(monitoring_visit_issues.router, prefix="/studies/{study_id}/monitoring", tags=["monitoring-visit-issues"])
 api_router.include_router(subject_histories.router, prefix="/studies/{study_id}/subjects/{subject_id}", tags=["subject-histories"])
 api_router.include_router(subject_pds.router, prefix="/studies/{study_id}/subjects/{subject_id}", tags=["subject-pds"])
@@ -37,6 +35,7 @@ api_router.include_router(study_subject_pds.router, prefix="/studies/{study_id}"
 api_router.include_router(faq_categories.router, prefix="/faqs/categories", tags=["faq-categories"])
 api_router.include_router(faqs.router, prefix="/faqs/items", tags=["faqs"])
 api_router.include_router(documents.router, prefix="", tags=["documents"])
+api_router.include_router(etmf.router, prefix="/etmf", tags=["etmf"])
 api_router.include_router(permission_monitoring.router)
 api_router.include_router(permission_templates.router)
 api_router.include_router(permission_templates.study_router, prefix="/studies/{study_id}", tags=["permission-templates"])

backend/app/api/v1/sites.py

@@ -79,7 +79,7 @@ async def create_site(
     module="sites",
     action="read",
     description="查询中心列表",
-    default_roles=["PM", "CRA", "PV", "MEDICAL_REVIEW", "IMP"],
+    default_roles=["PM", "CRA", "PV", "QA", "CTA"],
 )
 async def list_sites(
     study_id: uuid.UUID,

backend/app/api/v1/startup.py

@@ -53,7 +53,7 @@ async def _ensure_site_active(db: AsyncSession, site_id: uuid.UUID | None):
     "/feasibility",
     response_model=StartupFeasibilityRead,
     status_code=status.HTTP_201_CREATED,
-    dependencies=[Depends(require_api_permission("ethics:create"))],
+    dependencies=[Depends(require_api_permission("startup_initiation:create"))],
 )
 async def create_feasibility(
     study_id: uuid.UUID,
@@ -83,7 +83,7 @@ async def create_feasibility(
 @router.get(
     "/feasibility",
     response_model=list[StartupFeasibilityRead],
-    dependencies=[Depends(require_api_permission("ethics:read"))],
+    dependencies=[Depends(require_api_permission("startup_initiation:read"))],
 )
 async def list_feasibilities(
     study_id: uuid.UUID,
@@ -102,7 +102,7 @@ async def list_feasibilities(
 @router.get(
     "/feasibility/{record_id}",
     response_model=StartupFeasibilityRead,
-    dependencies=[Depends(require_api_permission("ethics:read"))],
+    dependencies=[Depends(require_api_permission("startup_initiation:read"))],
 )
 async def get_feasibility(
     study_id: uuid.UUID,
@@ -123,7 +123,7 @@ async def get_feasibility(
 @router.patch(
     "/feasibility/{record_id}",
     response_model=StartupFeasibilityRead,
-    dependencies=[Depends(require_api_permission("ethics:update"))],
+    dependencies=[Depends(require_api_permission("startup_initiation:update"))],
 )
 async def update_feasibility(
     study_id: uuid.UUID,
@@ -157,7 +157,7 @@ async def update_feasibility(
 @router.delete(
     "/feasibility/{record_id}",
     status_code=status.HTTP_204_NO_CONTENT,
-    dependencies=[Depends(require_api_permission("ethics:delete"))],
+    dependencies=[Depends(require_api_permission("startup_initiation:delete"))],
 )
 async def delete_feasibility(
     study_id: uuid.UUID,
@@ -190,7 +190,7 @@ async def delete_feasibility(
     "/ethics",
     response_model=StartupEthicsRead,
     status_code=status.HTTP_201_CREATED,
-    dependencies=[Depends(require_api_permission("ethics:create"))],
+    dependencies=[Depends(require_api_permission("startup_ethics:create"))],
 )
 async def create_ethics(
     study_id: uuid.UUID,
@@ -220,7 +220,7 @@ async def create_ethics(
 @router.get(
     "/ethics",
     response_model=list[StartupEthicsRead],
-    dependencies=[Depends(require_api_permission("ethics:read"))],
+    dependencies=[Depends(require_api_permission("startup_ethics:read"))],
 )
 async def list_ethics(
     study_id: uuid.UUID,
@@ -239,7 +239,7 @@ async def list_ethics(
 @router.get(
     "/ethics/{record_id}",
     response_model=StartupEthicsRead,
-    dependencies=[Depends(require_api_permission("ethics:read"))],
+    dependencies=[Depends(require_api_permission("startup_ethics:read"))],
 )
 async def get_ethics(
     study_id: uuid.UUID,
@@ -260,7 +260,7 @@ async def get_ethics(
 @router.patch(
     "/ethics/{record_id}",
     response_model=StartupEthicsRead,
-    dependencies=[Depends(require_api_permission("ethics:update"))],
+    dependencies=[Depends(require_api_permission("startup_ethics:update"))],
 )
 async def update_ethics(
     study_id: uuid.UUID,
@@ -294,7 +294,7 @@ async def update_ethics(
 @router.delete(
     "/ethics/{record_id}",
     status_code=status.HTTP_204_NO_CONTENT,
-    dependencies=[Depends(require_api_permission("ethics:delete"))],
+    dependencies=[Depends(require_api_permission("startup_ethics:delete"))],
 )
 async def delete_ethics(
     study_id: uuid.UUID,

backend/app/api/v1/study_subject_pds.py

@@ -3,7 +3,7 @@ import uuid
 from fastapi import APIRouter, Depends, HTTPException, status
 from sqlalchemy.ext.asyncio import AsyncSession
 
-from app.core.deps import get_cra_site_scope, get_current_user, get_db_session, require_study_member
+from app.core.deps import get_cra_site_scope, get_current_user, get_db_session, require_api_permission
 from app.crud import study as study_crud
 from app.crud import subject_pd as subject_pd_crud
 from app.schemas.subject_pd import SubjectPdSummaryRead
@@ -21,7 +21,7 @@ async def _ensure_study_exists(db: AsyncSession, study_id: uuid.UUID):
 @router.get(
     "/subject-pds",
     response_model=list[SubjectPdSummaryRead],
-    dependencies=[Depends(require_study_member())],
+    dependencies=[Depends(require_api_permission("subject_pds:list"))],
 )
 async def list_study_subject_pds(
     study_id: uuid.UUID,

backend/app/api/v1/subject_histories.py

@@ -66,7 +66,7 @@ async def create_history(
 @router.get(
     "/histories",
     response_model=list[SubjectHistoryRead],
-    dependencies=[Depends(require_api_permission("subject_histories:read"))],
+    dependencies=[Depends(require_api_permission("subject_histories:list"))],
 )
 async def list_histories(
     study_id: uuid.UUID,

backend/app/api/v1/subject_pds.py

@@ -64,7 +64,7 @@ def _normalize_choice(value: str | None, allowed: set[str], field_name: str) ->
 @router.get(
     "/pds",
     response_model=list[SubjectPdRead],
-    dependencies=[Depends(require_api_permission("subject_pds:read"))],
+    dependencies=[Depends(require_api_permission("subject_pds:list"))],
 )
 async def list_subject_pds(
     study_id: uuid.UUID,

backend/app/api/v1/visits.py

@@ -33,7 +33,7 @@ async def _ensure_subject_active(db: AsyncSession, subject) -> None:
 @router.get(
     "/",
     response_model=list[VisitRead],
-    dependencies=[Depends(require_api_permission("visits:read"))],
+    dependencies=[Depends(require_api_permission("visits:list"))],
 )
 async def list_visits(
     study_id: uuid.UUID,

backend/app/crud/acknowledgement.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 

backend/app/crud/distribution.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 

backend/app/crud/document_version.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 

backend/app/crud/member.py

@@ -1,5 +1,7 @@
 from __future__ import annotations
 
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 

backend/app/crud/overview.py

@@ -9,7 +9,7 @@ from sqlalchemy.ext.asyncio import AsyncSession
 from app.models.site import Site
 from app.models.startup_feasibility import StartupFeasibility
 from app.models.startup_ethics import StartupEthics
-from app.models.finance_contract import FinanceContract
+from app.models.contract_fee import ContractFee
 from app.models.kickoff_meeting import KickoffMeeting
 from app.models.subject import Subject
 
@@ -59,7 +59,7 @@ async def get_project_overview(db: AsyncSession, study_id: uuid.UUID) -> Dict:
         institution_status = "COMPLETED" if feas.get("approved_date") else "IN_PROGRESS" if feas.get("submit_date") else "NOT_STARTED"
         institution_completed = feas.get("approved_date")
         
-        # 伦理审批状态 - 依赖机构立项完成
+        # 伦理记录状态 - 依赖机构立项完成
         eth = ethics_data.get(site_id_str, {})
         if institution_status == "COMPLETED":
             ethics_status = "COMPLETED" if eth.get("approved_date") else "IN_PROGRESS" if eth.get("submit_date") else "NOT_STARTED"
@@ -68,7 +68,7 @@ async def get_project_overview(db: AsyncSession, study_id: uuid.UUID) -> Dict:
             ethics_status = "NOT_STARTED"
         ethics_completed = eth.get("approved_date") if institution_status == "COMPLETED" else None
         
-        # 合同签署状态 - 依赖伦理审批完成
+        # 合同签署状态 - 依赖伦理记录完成
         contract = contract_data.get(site_id_str, {})
         if ethics_status == "COMPLETED":
             contract_status = "COMPLETED" if contract.get("signed_date") else "NOT_STARTED"
@@ -202,26 +202,20 @@ async def _get_ethics_data(db: AsyncSession, study_id: uuid.UUID, site_ids: List
 
 async def _get_contract_data(db: AsyncSession, study_id: uuid.UUID, site_ids: List[uuid.UUID]) -> Dict:
     """获取各中心的合同签署数据"""
-    # FinanceContract 通过 site_name 关联，需要先获取site名称映射
-    stmt_sites = select(Site.id, Site.name).where(Site.id.in_(site_ids))
-    result = await db.execute(stmt_sites)
-    site_name_map = {row.name: str(row.id) for row in result.all()}
-    
     stmt = select(
-        FinanceContract.site_name,
+        ContractFee.center_id,
-        func.min(FinanceContract.signed_date).label("signed_date")
+        func.min(ContractFee.signed_date).label("signed_date")
     ).where(
-        FinanceContract.study_id == study_id
+        ContractFee.project_id == study_id,
-    ).group_by(FinanceContract.site_name)
+        ContractFee.center_id.in_(site_ids),
+    ).group_by(ContractFee.center_id)
     
     result = await db.execute(stmt)
     rows = result.all()
     
     data = {}
     for row in rows:
-        site_id_str = site_name_map.get(row.site_name)
+        data[str(row.center_id)] = {
-        if site_id_str:
-            data[site_id_str] = {
             "signed_date": row.signed_date.isoformat() if row.signed_date else None,
         }
     

backend/app/crud/site.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from pathlib import Path
 from typing import Iterable, Sequence
@@ -16,9 +18,8 @@ from app.models.distribution import Distribution
 from app.models.drug_shipment import DrugShipment
 from app.models.fee_attachment import FeeAttachment
 from app.models.finance import FinanceItem
-from app.models.finance_contract import FinanceContract
 from app.models.kickoff_meeting import KickoffMeeting
-from app.models.knowledge_note import KnowledgeNote
+from app.models.precaution import Precaution
 from app.models.milestone import Milestone
 from app.models.monitoring_visit_issue import MonitoringVisitIssue
 from app.models.site import Site
@@ -177,19 +178,11 @@ async def delete_site_and_related(db: AsyncSession, site: Site) -> None:
             )
         )
     ).scalars().all()
-    finance_contract_ids = (
+    precaution_ids = (
         await db.execute(
-            select(FinanceContract.id).where(
+            select(Precaution.id).where(
-                FinanceContract.study_id == study_id,
+                Precaution.study_id == study_id,
-                FinanceContract.site_name == site_name,
+                Precaution.site_name == site_name,
-            )
-        )
-    ).scalars().all()
-    knowledge_note_ids = (
-        await db.execute(
-            select(KnowledgeNote.id).where(
-                KnowledgeNote.study_id == study_id,
-                KnowledgeNote.site_name == site_name,
             )
         )
     ).scalars().all()
@@ -220,8 +213,7 @@ async def delete_site_and_related(db: AsyncSession, site: Site) -> None:
         "startup_kickoff_signin": kickoff_ids,
         "startup_kickoff_ppt": kickoff_ids,
         "training_authorization": training_ids,
-        "finance_contract": finance_contract_ids,
+        "precaution": precaution_ids,
-        "knowledge_note": knowledge_note_ids,
         "drug_shipment": drug_shipment_ids,
     }
     attachment_paths: list[str] = []
@@ -311,15 +303,9 @@ async def delete_site_and_related(db: AsyncSession, site: Site) -> None:
         )
     )
     await db.execute(
-        delete(FinanceContract).where(
+        delete(Precaution).where(
-            FinanceContract.study_id == study_id,
+            Precaution.study_id == study_id,
-            FinanceContract.site_name == site_name,
+            Precaution.site_name == site_name,
-        )
-    )
-    await db.execute(
-        delete(KnowledgeNote).where(
-            KnowledgeNote.study_id == study_id,
-            KnowledgeNote.site_name == site_name,
         )
     )
 

backend/app/crud/study.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 
@@ -99,7 +101,6 @@ async def delete(db: AsyncSession, study_id: uuid.UUID) -> None:
     from app.models.visit import Visit
     from app.models.ae import AdverseEvent
     from app.models.finance import FinanceItem
-    from app.models.finance_contract import FinanceContract
     from app.models.contract_fee import ContractFee
     from app.models.contract_fee_payment import ContractFeePayment
     from app.models.milestone import Milestone
@@ -111,7 +112,7 @@ async def delete(db: AsyncSession, study_id: uuid.UUID) -> None:
     from app.models.startup_feasibility import StartupFeasibility
     from app.models.startup_ethics import StartupEthics
     from app.models.kickoff_meeting import KickoffMeeting
-    from app.models.knowledge_note import KnowledgeNote
+    from app.models.precaution import Precaution
     from app.models.faq_category import FaqCategory
     from app.models.faq_item import FaqItem
     from app.models.faq_reply import FaqReply
@@ -129,8 +130,8 @@ async def delete(db: AsyncSession, study_id: uuid.UUID) -> None:
     await db.execute(sa_delete(FaqItem).where(FaqItem.study_id == study_id))
     await db.execute(sa_delete(FaqCategory).where(FaqCategory.study_id == study_id))
     
-    # 3. 删除知识库
+    # 3. 删除注意事项
-    await db.execute(sa_delete(KnowledgeNote).where(KnowledgeNote.study_id == study_id))
+    await db.execute(sa_delete(Precaution).where(Precaution.study_id == study_id))
     
     # 4. 删除启动相关
     await db.execute(sa_delete(KickoffMeeting).where(KickoffMeeting.study_id == study_id))
@@ -158,7 +159,6 @@ async def delete(db: AsyncSession, study_id: uuid.UUID) -> None:
         )
     )
     await db.execute(sa_delete(ContractFee).where(ContractFee.project_id == study_id))
-    await db.execute(sa_delete(FinanceContract).where(FinanceContract.study_id == study_id))
     await db.execute(sa_delete(FinanceItem).where(FinanceItem.study_id == study_id))
     
     # 10. 删除不良事件

backend/app/crud/user.py

@@ -1,5 +1,7 @@
 from __future__ import annotations
 
+from __future__ import annotations
+
 import uuid
 from typing import Sequence
 

backend/app/db/base.py

@@ -7,6 +7,7 @@ from app.models.site import Site  # noqa: F401
 from app.models.study_member import StudyMember  # noqa: F401
 from app.models.attachment import Attachment  # noqa: F401
 from app.models.audit_log import AuditLog  # noqa: F401
+from app.models.etmf import EtmfNode  # noqa: F401
 from app.models.document import Document  # noqa: F401
 from app.models.document_version import DocumentVersion  # noqa: F401
 from app.models.distribution import Distribution  # noqa: F401
@@ -17,7 +18,6 @@ from app.models.subject_pd import SubjectPd  # noqa: F401
 from app.models.visit import Visit  # noqa: F401
 from app.models.ae import AdverseEvent  # noqa: F401
 from app.models.finance import FinanceItem  # noqa: F401
-from app.models.finance_contract import FinanceContract  # noqa: F401
 from app.models.contract_fee import ContractFee  # noqa: F401
 from app.models.contract_fee_payment import ContractFeePayment  # noqa: F401
 from app.models.fee_attachment import FeeAttachment  # noqa: F401
@@ -28,7 +28,7 @@ from app.models.startup_feasibility import StartupFeasibility  # noqa: F401
 from app.models.startup_ethics import StartupEthics  # noqa: F401
 from app.models.kickoff_meeting import KickoffMeeting  # noqa: F401
 from app.models.training_authorization import TrainingAuthorization  # noqa: F401
-from app.models.knowledge_note import KnowledgeNote  # noqa: F401
+from app.models.precaution import Precaution  # noqa: F401
 from app.models.subject_history import SubjectHistory  # noqa: F401
 from app.models.faq_category import FaqCategory  # noqa: F401
 from app.models.faq_item import FaqItem  # noqa: F401

backend/app/models/kickoff_meeting.py

@@ -18,7 +18,7 @@ class KickoffMeeting(Base):
     study_id: Mapped[uuid.UUID] = mapped_column(UUID(as_uuid=True), ForeignKey("studies.id"), index=True, nullable=False)
     site_id: Mapped[Optional[uuid.UUID]] = mapped_column(UUID(as_uuid=True), ForeignKey("sites.id"), index=True, nullable=True)
     kickoff_date: Mapped[Optional[date]] = mapped_column(Date, nullable=True)
-    attendees: Mapped[list[str] | None] = mapped_column(JSON, nullable=True)
+    attendees: Mapped[Optional[list[str]]] = mapped_column(JSON, nullable=True)
     created_by: Mapped[Optional[uuid.UUID]] = mapped_column(UUID(as_uuid=True), ForeignKey("users.id"), nullable=True)
     created_at: Mapped[datetime] = mapped_column(DateTime(timezone=True), nullable=False, server_default=func.now())
     updated_at: Mapped[datetime] = mapped_column(

backend/app/models/study_setup_config.py

@@ -22,8 +22,8 @@ class StudySetupConfig(Base):
     version: Mapped[int] = mapped_column(Integer, nullable=False, default=1)
     config: Mapped[dict] = mapped_column(JSONB_TYPE, nullable=False)
     publish_status: Mapped[str] = mapped_column(default="DRAFT", nullable=False)
-    published_config: Mapped[dict | None] = mapped_column(JSONB_TYPE, nullable=True)
+    published_config: Mapped[Optional[dict]] = mapped_column(JSONB_TYPE, nullable=True)
-    published_project_snapshot: Mapped[dict | None] = mapped_column(JSONB_TYPE, nullable=True)
+    published_project_snapshot: Mapped[Optional[dict]] = mapped_column(JSONB_TYPE, nullable=True)
     current_branch_name: Mapped[str] = mapped_column(nullable=False, default="main")
     active_branch_base_version_id: Mapped[Optional[uuid.UUID]] = mapped_column(
         UUID(as_uuid=True), ForeignKey("study_setup_config_versions.id", ondelete="SET NULL"), nullable=True

backend/app/models/study_setup_config_version.py

@@ -38,7 +38,7 @@ class StudySetupConfigVersion(Base):
         UUID(as_uuid=True), ForeignKey("study_setup_config_versions.id", ondelete="SET NULL"), nullable=True
     )
     config: Mapped[dict] = mapped_column(JSONB_TYPE, nullable=False)
-    published_project_snapshot: Mapped[dict | None] = mapped_column(JSONB_TYPE, nullable=True)
+    published_project_snapshot: Mapped[Optional[dict]] = mapped_column(JSONB_TYPE, nullable=True)
     published_by: Mapped[Optional[uuid.UUID]] = mapped_column(UUID(as_uuid=True), ForeignKey("users.id"), nullable=True)
     published_at: Mapped[datetime] = mapped_column(DateTime(timezone=True), nullable=False, server_default=func.now())
     created_at: Mapped[datetime] = mapped_column(DateTime(timezone=True), nullable=False, server_default=func.now())

backend/app/schemas/notification.py

@@ -1,3 +1,5 @@
+from __future__ import annotations
+
 import uuid
 from datetime import datetime
 

frontend/src/api/aes.ts

@@ -4,6 +4,9 @@ import type { ApiListResponse } from "../types/api";
 export const fetchAes = (studyId: string, params?: Record<string, any>) =>
   apiGet<ApiListResponse<any>>(`/api/v1/studies/${studyId}/aes/`, { params });
 
+export const fetchRiskIssueAes = (studyId: string, params?: Record<string, any>) =>
+  apiGet<ApiListResponse<any>>(`/api/v1/studies/${studyId}/aes/summary`, { params });
+
 export const createAe = (studyId: string, payload: Record<string, any>) =>
   apiPost(`/api/v1/studies/${studyId}/aes/`, payload);
 

frontend/src/components/Layout.vue

@@ -88,21 +88,17 @@
             <el-menu-item v-if="canAccessProjectPath('/risk-issues/pd')" index="/risk-issues/pd">{{ TEXT.menu.riskIssuePd }}</el-menu-item>
             <el-menu-item v-if="canAccessProjectPath('/risk-issues/monitoring-visits')" index="/risk-issues/monitoring-visits">{{ TEXT.menu.riskIssueMonitoringVisits }}</el-menu-item>
           </el-sub-menu>
-          <el-menu-item v-if="canAccessProjectPath('/monitoring-audit')" index="/monitoring-audit">
-            <el-icon><ChatDotRound /></el-icon>
-            <span>{{ TEXT.menu.monitoringAudit }}</span>
-          </el-menu-item>
           <el-menu-item v-if="canAccessProjectPath('/etmf')" index="/etmf">
             <el-icon><Flag /></el-icon>
             <span>{{ TEXT.menu.etmf }}</span>
           </el-menu-item>
-          <el-sub-menu v-if="canAccessAnyProjectPath(['/knowledge/medical-consult', '/knowledge/notes', '/knowledge/support-files', '/knowledge/instruction-files'])" index="knowledge">
+          <el-sub-menu v-if="canAccessAnyProjectPath(['/knowledge/medical-consult', '/knowledge/precautions', '/knowledge/support-files', '/knowledge/instruction-files'])" index="knowledge">
             <template #title>
               <el-icon><Notebook /></el-icon>
               <span>{{ TEXT.menu.sharedLibrary }}</span>
             </template>
             <el-menu-item v-if="canAccessProjectPath('/knowledge/medical-consult')" index="/knowledge/medical-consult">{{ TEXT.menu.knowledgeMedicalConsult }}</el-menu-item>
-            <el-menu-item v-if="canAccessProjectPath('/knowledge/notes')" index="/knowledge/notes">{{ TEXT.menu.knowledgeNotes }}</el-menu-item>
+            <el-menu-item v-if="canAccessProjectPath('/knowledge/precautions')" index="/knowledge/precautions">{{ TEXT.menu.knowledgeNotes }}</el-menu-item>
             <el-menu-item v-if="canAccessProjectPath('/knowledge/support-files')" index="/knowledge/support-files">{{ TEXT.menu.knowledgeSupportFiles }}</el-menu-item>
             <el-menu-item v-if="canAccessProjectPath('/knowledge/instruction-files')" index="/knowledge/instruction-files">{{ TEXT.menu.knowledgeInstructionFiles }}</el-menu-item>
           </el-sub-menu>
@@ -217,7 +213,7 @@ import { fetchStudies } from "../api/studies";
 import { fetchSites } from "../api/sites";
 import { TEXT } from "../locales";
 import {
-  User, Suitcase, House, Calendar, Flag, ChatDotRound,
+  User, Suitcase, House, Calendar, Flag,
   CircleCheck, Box, Coin, Notebook, Document, ArrowDown, SwitchButton, Files, Key
 } from "@element-plus/icons-vue";
 import { ElMessage } from "element-plus";
@@ -260,7 +256,6 @@ const activeMenu = computed(() => {
   if (path.startsWith("/project/milestones")) return "/project/milestones";
   if (path.startsWith("/project/")) return "/project/overview";
   if (path.startsWith("/fees/contracts")) return "/fees/contracts";
-  if (path.startsWith("/finance/contracts")) return "/fees/contracts";
   if (path.startsWith("/drug/shipments")) return "/drug/shipments";
   if (path.startsWith("/materials/equipment")) return "/materials/equipment";
   if (path.startsWith("/file-versions") || path.startsWith("/trial/") || path.startsWith("/documents/")) return "/file-versions";
@@ -273,10 +268,9 @@ const activeMenu = computed(() => {
   if (path.startsWith("/risk-issues/pd")) return "/risk-issues/pd";
   if (path.startsWith("/risk-issues/monitoring-visits")) return "/risk-issues/monitoring-visits";
   if (path.startsWith("/risk-issues")) return "/risk-issues/sae";
-  if (path.startsWith("/monitoring-audit") || path.startsWith("/monitoring") || path.startsWith("/audit")) return "/monitoring-audit";
   if (path.startsWith("/etmf")) return "/etmf";
   if (path.startsWith("/knowledge/medical-consult")) return "/knowledge/medical-consult";
-  if (path.startsWith("/knowledge/notes")) return "/knowledge/notes";
+  if (path.startsWith("/knowledge/precautions")) return "/knowledge/precautions";
   if (path.startsWith("/knowledge/support-files")) return "/knowledge/support-files";
   if (path.startsWith("/knowledge/instruction-files")) return "/knowledge/instruction-files";
   if (path.startsWith("/projects/")) return "/admin/projects";
@@ -342,14 +336,13 @@ const breadcrumbs = computed(() => {
       "/risk-issues/sae": { label: TEXT.menu.riskIssueSae, path: "/risk-issues/sae" },
       "/risk-issues/pd": { label: TEXT.menu.riskIssuePd, path: "/risk-issues/pd" },
       "/risk-issues/monitoring-visits": { label: TEXT.menu.riskIssueMonitoringVisits, path: "/risk-issues/monitoring-visits" },
-      "/monitoring-audit": { label: TEXT.menu.monitoringAudit, path: "/monitoring-audit" },
       "/etmf": { label: TEXT.menu.etmf, path: "/etmf" },
       "/startup/feasibility": { label: TEXT.menu.startupFeasibilityEthics, path: "/startup/feasibility-ethics" },
       "/startup/ethics": { label: TEXT.menu.startupFeasibilityEthics, path: "/startup/feasibility-ethics" },
       "/startup/kickoff": { label: TEXT.menu.startupMeetingAuth, path: "/startup/meeting-auth" },
       "/startup/training": { label: TEXT.menu.startupMeetingAuth, path: "/startup/meeting-auth" },
       "/knowledge/medical-consult": { label: TEXT.menu.knowledgeMedicalConsult, path: "/knowledge/medical-consult" },
-      "/knowledge/notes": { label: TEXT.menu.knowledgeNotes, path: "/knowledge/notes" },
+      "/knowledge/precautions": { label: TEXT.menu.knowledgeNotes, path: "/knowledge/precautions" },
     };
 
     let matchedModule = null;

frontend/src/router/index.ts

@@ -22,7 +22,6 @@ import ProjectDetail from "../views/admin/ProjectDetail.vue";
 import ProfileSettings from "../views/ProfileSettings.vue";
 import ProjectOverview from "../views/ia/ProjectOverview.vue";
 import ProjectMilestones from "../views/ia/ProjectMilestones.vue";
-import FinanceContracts from "../views/ia/FinanceContracts.vue";
 import FeeContracts from "../views/fees/ContractFees.vue";
 import FeeContractForm from "../views/fees/ContractFeeForm.vue";
 import FeeContractDetail from "../views/fees/ContractFeeDetail.vue";
@@ -37,14 +36,11 @@ import SubjectManagement from "../views/ia/SubjectManagement.vue";
 import RiskIssueSae from "../views/ia/RiskIssueSae.vue";
 import RiskIssuePd from "../views/ia/RiskIssuePd.vue";
 import RiskIssueMonitoringVisits from "../views/ia/RiskIssueMonitoringVisits.vue";
-import MonitoringAuditPlaceholder from "../views/ia/MonitoringAuditPlaceholder.vue";
 import EtmfPlaceholder from "../views/ia/EtmfPlaceholder.vue";
 import KnowledgeMedicalConsult from "../views/ia/KnowledgeMedicalConsult.vue";
-import KnowledgeNotes from "../views/ia/KnowledgeNotes.vue";
+import Precautions from "../views/ia/Precautions.vue";
 import KnowledgeSupportFiles from "../views/ia/KnowledgeSupportFiles.vue";
 import KnowledgeInstructionFiles from "../views/ia/KnowledgeInstructionFiles.vue";
-import ContractForm from "../views/finance/ContractForm.vue";
-import ContractDetail from "../views/finance/ContractDetail.vue";
 import ShipmentForm from "../views/drug/ShipmentForm.vue";
 import ShipmentDetail from "../views/drug/ShipmentDetail.vue";
 import FeasibilityForm from "../views/startup/FeasibilityForm.vue";
@@ -55,8 +51,8 @@ import KickoffForm from "../views/startup/KickoffForm.vue";
 import KickoffDetail from "../views/startup/KickoffDetail.vue";
 import TrainingForm from "../views/startup/TrainingForm.vue";
 import TrainingDetail from "../views/startup/TrainingDetail.vue";
-import NoteForm from "../views/knowledge/NoteForm.vue";
+import PrecautionForm from "../views/knowledge/PrecautionForm.vue";
-import NoteDetail from "../views/knowledge/NoteDetail.vue";
+import PrecautionDetail from "../views/knowledge/PrecautionDetail.vue";
 import SubjectForm from "../views/subjects/SubjectForm.vue";
 import SubjectDetail from "../views/subjects/SubjectDetail.vue";
 import { TEXT } from "../locales";
@@ -103,12 +99,6 @@ const routes: RouteRecordRaw[] = [
         component: ProjectMilestones,
         meta: { title: TEXT.menu.projectMilestones, requiresStudy: true },
       },
-      {
-        path: "finance/contracts",
-        name: "FinanceContracts",
-        component: FinanceContracts,
-        meta: { title: TEXT.menu.financeContracts, requiresStudy: true },
-      },
       {
         path: "fees/contracts",
         name: "FeeContracts",
@@ -133,24 +123,6 @@ const routes: RouteRecordRaw[] = [
         component: FeeContractForm,
         meta: { title: TEXT.common.actions.edit + TEXT.menu.feeContracts, requiresStudy: true },
       },
-      {
-        path: "finance/contracts/new",
-        name: "FinanceContractNew",
-        component: ContractForm,
-        meta: { title: TEXT.common.actions.add + TEXT.menu.financeContracts, requiresStudy: true },
-      },
-      {
-        path: "finance/contracts/:contractId",
-        name: "FinanceContractDetail",
-        component: ContractDetail,
-        meta: { title: TEXT.modules.financeContracts.detailTitle, requiresStudy: true },
-      },
-      {
-        path: "finance/contracts/:contractId/edit",
-        name: "FinanceContractEdit",
-        component: ContractForm,
-        meta: { title: TEXT.common.actions.edit + TEXT.menu.financeContracts, requiresStudy: true },
-      },
       {
         path: "drug/shipments",
         name: "DrugShipments",
@@ -329,20 +301,6 @@ const routes: RouteRecordRaw[] = [
         component: RiskIssueMonitoringVisits,
         meta: { title: TEXT.menu.riskIssueMonitoringVisits, requiresStudy: true },
       },
-      {
-        path: "monitoring-audit",
-        name: "MonitoringAuditPlaceholder",
-        component: MonitoringAuditPlaceholder,
-        meta: { title: TEXT.menu.monitoringAudit, requiresStudy: true },
-      },
-      {
-        path: "monitoring",
-        redirect: "/monitoring-audit",
-      },
-      {
-        path: "audit",
-        redirect: "/monitoring-audit",
-      },
       {
         path: "etmf",
         name: "EtmfPlaceholder",
@@ -362,27 +320,27 @@ const routes: RouteRecordRaw[] = [
         meta: { title: TEXT.modules.knowledgeMedicalConsult.detailTitle, requiresStudy: true },
       },
       {
-        path: "knowledge/notes",
+        path: "knowledge/precautions",
-        name: "KnowledgeNotes",
+        name: "Precautions",
-        component: KnowledgeNotes,
+        component: Precautions,
         meta: { title: TEXT.menu.knowledgeNotes, requiresStudy: true },
       },
       {
-        path: "knowledge/notes/new",
+        path: "knowledge/precautions/new",
-        name: "KnowledgeNoteNew",
+        name: "PrecautionNew",
-        component: NoteForm,
+        component: PrecautionForm,
         meta: { title: TEXT.common.actions.add + TEXT.menu.knowledgeNotes, requiresStudy: true },
       },
       {
-        path: "knowledge/notes/:noteId",
+        path: "knowledge/precautions/:id",
-        name: "KnowledgeNoteDetail",
+        name: "PrecautionDetail",
-        component: NoteDetail,
+        component: PrecautionDetail,
         meta: { title: TEXT.modules.knowledgeNotes.detailTitle, requiresStudy: true },
       },
       {
-        path: "knowledge/notes/:noteId/edit",
+        path: "knowledge/precautions/:id/edit",
-        name: "KnowledgeNoteEdit",
+        name: "PrecautionEdit",
-        component: NoteForm,
+        component: PrecautionForm,
         meta: { title: TEXT.common.actions.edit + TEXT.menu.knowledgeNotes, requiresStudy: true },
       },
       {

frontend/src/views/FaqDetail.vue

@@ -51,7 +51,7 @@
           :quote-item="quoteReply"
           :member-map="memberMap"
           :user-map="userMap"
-          :allow-attachments="true"
+          :allow-attachments="canUploadReplyAttachment"
           @submit="submitReply"
           @clear-quote="clearQuote"
         />
@@ -107,7 +107,10 @@ import { listMembers } from "../api/members";
 import { fetchAttachments, uploadAttachment } from "../api/attachments";
 import { displayDateTime, displayUser, getMemberDisplayName, getUserDisplayName } from "../utils/display";
 import { useAuthStore } from "../store/auth";
+import { useStudyStore } from "../store/study";
 import { usePermission } from "../utils/permission";
+import { getAttachmentPermissionKey } from "../utils/attachmentPermissions";
+import { isApiPermissionAllowed } from "../utils/apiPermissionValue";
 import FaqItemForm from "../components/FaqItemForm.vue";
 import ThreadComposer from "../components/ThreadComposer.vue";
 import ThreadList from "../components/ThreadList.vue";
@@ -115,6 +118,7 @@ import { TEXT } from "../locales";
 
 const route = useRoute();
 const auth = useAuthStore();
+const study = useStudyStore();
 const item = ref<any>(null);
 const loading = ref(false);
 const categories = ref<any[]>([]);
@@ -136,6 +140,14 @@ const canReply = computed(() => {
   return can("faq.reply");
 });
 
+const canUploadReplyAttachment = computed(() => {
+  if (!item.value?.study_id) return false;
+  if (auth.user?.is_admin) return true;
+  const role = study.currentStudyRole || (study.currentStudy as any)?.role_in_study;
+  const operationKey = getAttachmentPermissionKey("faq_replies", "create");
+  return !!role && !!operationKey && isApiPermissionAllowed(study.currentPermissions?.[role]?.[operationKey]);
+});
+
 const canDeleteReply = (reply: any) => {
   if (reply.is_deleted) return false;
   if (auth.user?.is_admin) return true;
@@ -273,7 +285,7 @@ const submitReply = async () => {
       quote_reply_id: quoteReply.value?.id || null,
     });
     const created = data as any;
-    if (replyFiles.value.length && created?.id) {
+    if (canUploadReplyAttachment.value && replyFiles.value.length && created?.id) {
       try {
         for (const file of replyFiles.value) {
           if (!file.raw) continue;

frontend/src/views/documents/DocumentDetail.vue

@@ -362,7 +362,7 @@ const uploadRules: FormRules = {
 };
 
 const roleOptions = computed(() => {
-  const fallbackRoles = ["CRA", "PM", "IMP", "PV", "MEDICAL_REVIEW"];
+  const fallbackRoles = ["CRA", "PM", "CTA", "PV", "QA"];
   const roles = new Set(members.value.map((m) => m.role_in_study).filter(Boolean));
   const values = roles.size ? Array.from(roles) : fallbackRoles;
   return values.map((value) => ({

frontend/src/views/ia/AuditPlaceholder.vue

@@ -1,13 +0,0 @@
-<template>
-  <ModulePlaceholder
-    :title="TEXT.modules.audit.title"
-    :subtitle="TEXT.modules.audit.subtitle"
-    :list-title="TEXT.modules.audit.listTitle"
-    :empty-description="TEXT.modules.audit.emptyDescription"
-  />
-</template>
-
-<script setup lang="ts">
-import ModulePlaceholder from "../../components/ModulePlaceholder.vue";
-import { TEXT } from "../../locales";
-</script>

frontend/src/views/ia/MonitoringAuditPlaceholder.vue

@@ -1,13 +0,0 @@
-<template>
-  <ModulePlaceholder
-    :title="TEXT.modules.monitoringAudit.title"
-    :subtitle="TEXT.modules.monitoringAudit.subtitle"
-    :list-title="TEXT.modules.monitoringAudit.listTitle"
-    :empty-description="TEXT.modules.monitoringAudit.emptyDescription"
-  />
-</template>
-
-<script setup lang="ts">
-import ModulePlaceholder from "../../components/ModulePlaceholder.vue";
-import { TEXT } from "../../locales";
-</script>

frontend/src/views/ia/MonitoringPlaceholder.vue

@@ -1,13 +0,0 @@
-<template>
-  <ModulePlaceholder
-    :title="TEXT.modules.monitoring.title"
-    :subtitle="TEXT.modules.monitoring.subtitle"
-    :list-title="TEXT.modules.monitoring.listTitle"
-    :empty-description="TEXT.modules.monitoring.emptyDescription"
-  />
-</template>
-
-<script setup lang="ts">
-import ModulePlaceholder from "../../components/ModulePlaceholder.vue";
-import { TEXT } from "../../locales";
-</script>

frontend/src/views/ia/RiskIssueMonitoringVisits.test.ts

@@ -0,0 +1,31 @@
+import { describe, expect, it } from "vitest";
+import { readFileSync } from "node:fs";
+import { resolve } from "node:path";
+
+const readRiskIssueMonitoringVisits = () => readFileSync(resolve(__dirname, "./RiskIssueMonitoringVisits.vue"), "utf8");
+
+describe("RiskIssueMonitoringVisits permissions", () => {
+  it("gates monitoring visit issue actions by concrete API permissions", () => {
+    const source = readRiskIssueMonitoringVisits();
+
+    expect(source).toContain("useAuthStore");
+    expect(source).toContain("isSystemAdmin");
+    expect(source).toContain("getProjectRole");
+    expect(source).toContain("isApiPermissionAllowed");
+    [
+      "monitoring_issues:list",
+      "monitoring_issues:read",
+      "monitoring_issues:create",
+      "monitoring_issues:update",
+      "monitoring_issues:delete",
+    ].forEach((operationKey) => {
+      expect(source).toContain(operationKey);
+    });
+    expect(source).toContain('v-if="canCreateIssue"');
+    expect(source).toContain('v-if="canListIssues"');
+    expect(source).toContain('v-if="canReadIssue"');
+    expect(source).toContain('v-if="canUpdateIssue"');
+    expect(source).toContain('v-if="canDeleteIssue"');
+    expect(source).toContain("const canSaveIssue = computed(() => (formMode.value === \"edit\" ? canUpdateIssue.value : canCreateIssue.value));");
+  });
+});

frontend/src/views/ia/RiskIssueMonitoringVisits.vue

@@ -105,7 +105,7 @@
           </div>
           <div class="template-toolbar">
             <div class="toolbar-left">
-              <el-button class="toolbar-button toolbar-button-primary" type="primary" @click="openCreateDialog">
+              <el-button v-if="canCreateIssue" class="toolbar-button toolbar-button-primary" type="primary" @click="openCreateDialog">
                 <el-icon><Plus /></el-icon>
                 <span>新增</span>
               </el-button>
@@ -117,7 +117,14 @@
                 <el-icon><CircleCheck /></el-icon>
                 <span>一键完成</span>
               </el-button>
-              <el-button class="toolbar-button toolbar-button-success" type="success" plain :loading="exporting" @click="handleExportExcel">
+              <el-button
+                v-if="canListIssues"
+                class="toolbar-button toolbar-button-success"
+                type="success"
+                plain
+                :loading="exporting"
+                @click="handleExportExcel"
+              >
                 <el-icon><Download /></el-icon>
                 <span>导出</span>
               </el-button>
@@ -126,6 +133,7 @@
                 <span>问题导入模板</span>
               </el-button>
               <el-upload
+                v-if="canCreateIssue"
                 ref="importUploadRef"
                 :auto-upload="false"
                 :show-file-list="false"
@@ -166,12 +174,12 @@
             <el-table-column prop="recommendation" label="建议" min-width="190" show-overflow-tooltip />
             <el-table-column prop="center_query" label="中心质疑" min-width="180" show-overflow-tooltip />
             <el-table-column prop="center_latest_reply" label="中心最新回复" min-width="180" show-overflow-tooltip />
-            <el-table-column label="操作" width="140" align="center">
+            <el-table-column v-if="canReadIssue || canUpdateIssue || canDeleteIssue" label="操作" width="140" align="center">
               <template #default="{ row }">
                 <div class="action-cell">
-                  <el-button class="action-btn" link type="primary" size="small" @click="openViewDialog(row)">查看</el-button>
+                  <el-button v-if="canReadIssue" class="action-btn" link type="primary" size="small" @click="openViewDialog(row)">查看</el-button>
-                  <el-button class="action-btn" link type="primary" size="small" @click="openEditDialog(row)">编辑</el-button>
+                  <el-button v-if="canUpdateIssue" class="action-btn" link type="primary" size="small" @click="openEditDialog(row)">编辑</el-button>
-                  <el-button class="action-btn" link type="danger" size="small" @click="removeIssue(row)">删除</el-button>
+                  <el-button v-if="canDeleteIssue" class="action-btn" link type="danger" size="small" @click="removeIssue(row)">删除</el-button>
                 </div>
               </template>
             </el-table-column>
@@ -403,7 +411,7 @@
         <template #footer>
           <div class="editor-footer">
             <el-button @click="formDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-            <el-button type="primary" :loading="saving" @click="submitForm">{{ TEXT.common.actions.save }}</el-button>
+            <el-button type="primary" :loading="saving" :disabled="!canSaveIssue" @click="submitForm">{{ TEXT.common.actions.save }}</el-button>
           </div>
         </template>
       </el-drawer>
@@ -460,9 +468,12 @@ import {
 import { fetchSites } from "../../api/sites";
 import StateEmpty from "../../components/StateEmpty.vue";
 import { TEXT } from "../../locales";
+import { useAuthStore } from "../../store/auth";
 import { useStudyStore } from "../../store/study";
 import type { Site } from "../../types/api";
+import { isApiPermissionAllowed } from "../../utils/apiPermissionValue";
 import { displayDateTime } from "../../utils/display";
+import { getProjectRole, isSystemAdmin } from "../../utils/roles";
 
 interface MonitoringIssueRow {
   id: string;
@@ -499,6 +510,7 @@ interface MonitoringIssueRow {
 }
 type DateRange = [string, string] | [];
 
+const auth = useAuthStore();
 const study = useStudyStore();
 const loading = ref(false);
 const saving = ref(false);
@@ -515,6 +527,19 @@ const viewIssue = ref<MonitoringIssueRow | null>(null);
 const sitesLoading = ref(false);
 const siteOptions = ref<Array<Pick<Site, "id" | "name" | "is_active">>>([]);
 const siteMap = ref<Record<string, string>>({});
+const projectRole = computed(() => getProjectRole(study.currentStudy, study.currentStudyRole));
+const canUseApiPermission = (operationKey: string) => {
+  if (isSystemAdmin(auth.user)) return true;
+  const role = projectRole.value;
+  if (!role) return false;
+  return isApiPermissionAllowed(study.currentPermissions?.[role]?.[operationKey]);
+};
+const canListIssues = computed(() => canUseApiPermission("monitoring_issues:list"));
+const canReadIssue = computed(() => canUseApiPermission("monitoring_issues:read"));
+const canCreateIssue = computed(() => canUseApiPermission("monitoring_issues:create"));
+const canUpdateIssue = computed(() => canUseApiPermission("monitoring_issues:update"));
+const canDeleteIssue = computed(() => canUseApiPermission("monitoring_issues:delete"));
+const canSaveIssue = computed(() => (formMode.value === "edit" ? canUpdateIssue.value : canCreateIssue.value));
 
 const currentProjectCenter = computed(() => study.currentStudy?.name || study.currentStudy?.project_full_name || "");
 
@@ -802,6 +827,7 @@ const resetFiltersForStudy = () => {
 };
 
 const openCreateDialog = () => {
+  if (!canCreateIssue.value) return;
   resetCreateForm();
   formMode.value = "create";
   editingIssueId.value = "";
@@ -810,7 +836,7 @@ const openCreateDialog = () => {
 
 const openEditDialog = async (row: MonitoringIssueRow) => {
   const studyId = study.currentStudy?.id;
-  if (!studyId || !row?.id) return;
+  if (!studyId || !row?.id || !canUpdateIssue.value) return;
   try {
     const { data } = await getMonitoringVisitIssue(studyId, row.id);
     const issue = (data || row) as MonitoringIssueRow;
@@ -825,7 +851,7 @@ const openEditDialog = async (row: MonitoringIssueRow) => {
 
 const openViewDialog = async (row: MonitoringIssueRow) => {
   const studyId = study.currentStudy?.id;
-  if (!studyId || !row?.id) return;
+  if (!studyId || !row?.id || !canReadIssue.value) return;
   try {
     const { data } = await getMonitoringVisitIssue(studyId, row.id);
     viewIssue.value = (data || row) as MonitoringIssueRow;
@@ -837,7 +863,7 @@ const openViewDialog = async (row: MonitoringIssueRow) => {
 
 const submitForm = async () => {
   const studyId = study.currentStudy?.id;
-  if (!studyId) return;
+  if (!studyId || !canSaveIssue.value) return;
   const ok = await createFormRef.value?.validate().catch(() => false);
   if (!ok) return;
 
@@ -891,7 +917,7 @@ const submitForm = async () => {
 
 const removeIssue = async (row: MonitoringIssueRow) => {
   const studyId = study.currentStudy?.id;
-  if (!studyId || !row?.id) return;
+  if (!studyId || !row?.id || !canDeleteIssue.value) return;
   const confirmed = await ElMessageBox.confirm(`确认删除问题「${row.issue_no}」？`, TEXT.common.labels.tips).catch(() => null);
   if (!confirmed) return;
 
@@ -914,7 +940,7 @@ const getFilename = (header?: string | null) => {
 
 const handleExportExcel = async () => {
   const studyId = study.currentStudy?.id;
-  if (!studyId) return;
+  if (!studyId || !canListIssues.value) return;
   if (filteredItems.value.length === 0) {
     ElMessage.warning("暂无可导出数据");
     return;
@@ -964,7 +990,7 @@ const handleExportExcel = async () => {
 
 const onImportChange = async (uploadFile: UploadFile) => {
   const studyId = study.currentStudy?.id;
-  if (!studyId) return;
+  if (!studyId || !canCreateIssue.value) return;
   const file = uploadFile.raw;
   if (!file) return;
 

frontend/src/views/ia/RiskIssueSae.vue

@@ -94,7 +94,7 @@ import { useRouter } from "vue-router";
 import { ElMessage } from "element-plus";
 import { CircleCheck, Location, Search, Warning } from "@element-plus/icons-vue";
 import { useStudyStore } from "../../store/study";
-import { fetchAes } from "../../api/aes";
+import { fetchRiskIssueAes } from "../../api/aes";
 import { fetchSubjects } from "../../api/subjects";
 import { fetchSites } from "../../api/sites";
 import { displayDate, displayEnum } from "../../utils/display";
@@ -166,7 +166,7 @@ const load = async () => {
   loading.value = true;
   try {
     await Promise.all([loadSites(studyId), loadSubjects(studyId)]);
-    const { data } = await fetchAes(studyId);
+    const { data } = await fetchRiskIssueAes(studyId);
     items.value = (Array.isArray(data) ? data : data.items || []).sort((a: any, b: any) =>
       String(b.updated_at || "").localeCompare(String(a.updated_at || ""))
     );

frontend/src/views/ia/project-overview/overview.adapter.ts

@@ -69,7 +69,7 @@ export const STAGE_ORDER: Array<{
   completedKey: StageCompletionKey;
 }> = [
     { key: "institution_initiation_status", label: "机构立项", completedKey: "institution_initiation_completed_at" },
-    { key: "ethics_status", label: "伦理审批", completedKey: "ethics_completed_at" },
+    { key: "ethics_status", label: "伦理记录", completedKey: "ethics_completed_at" },
     { key: "contract_sign_status", label: "合同签署", completedKey: "contract_sign_completed_at" },
     { key: "startup_status", label: "启动", completedKey: "startup_completed_at" },
     { key: "enrollment_status", label: "入组", completedKey: "enrollment_completed_at" },

frontend/src/views/subjects/SubjectDetail.test.ts

@@ -48,4 +48,45 @@ describe("SubjectDetail medication adherence", () => {
     expect(source).toContain("row.window_start === row.planned_date && row.window_end === row.planned_date");
     expect(source).toContain("return \"不适用\";");
   });
+
+  it("gates participant subresource mutations by concrete API permissions", () => {
+    const source = readSubjectDetail();
+
+    expect(source).toContain("isApiPermissionAllowed");
+    expect(source).toContain("getProjectRole");
+    expect(source).toContain("isSystemAdmin");
+    [
+      "subjects:update",
+      "subject_histories:create",
+      "subject_histories:update",
+      "subject_histories:delete",
+      "visits:create",
+      "visits:update",
+      "visits:delete",
+      "subject_aes:create",
+      "subject_aes:list",
+      "subject_aes:update",
+      "subject_aes:delete",
+      "subject_pds:create",
+      "subject_pds:list",
+      "subject_pds:update",
+      "subject_pds:delete",
+    ].forEach((operationKey) => {
+      expect(source).toContain(operationKey);
+    });
+    expect(source).toContain("v-if=\"currentTabAction.allowed\"");
+    expect(source).toContain("v-if=\"canUpdateHistory || canDeleteHistory\"");
+    expect(source).toContain("v-if=\"canUpdateVisit || canDeleteVisit\"");
+    expect(source).toContain("v-if=\"canUpdateAe || canDeleteAe\"");
+    expect(source).toContain("v-if=\"canUpdatePd || canDeletePd\"");
+    expect(source).toContain("const canSaveHistory = computed(() => (historyEditingId.value ? canUpdateHistory.value : canCreateHistory.value));");
+    expect(source).toContain("const canSaveVisit = computed(() => (visitEditingId.value ? canUpdateVisit.value : canCreateVisit.value));");
+    expect(source).toContain("const canSaveAe = computed(() => (aeEditingId.value ? canUpdateAe.value : canCreateAe.value));");
+    expect(source).toContain("const canSavePd = computed(() => (pdEditingId.value ? canUpdatePd.value : canCreatePd.value));");
+    expect(source).toContain("const canCreateAe = computed(() => canUseApiPermission(\"subject_aes:create\"));");
+    expect(source).toContain("const canUpdateAe = computed(() => canUseApiPermission(\"subject_aes:update\"));");
+    expect(source).toContain("const canDeleteAe = computed(() => canUseApiPermission(\"subject_aes:delete\"));");
+    expect(source).toContain("const canListAe = computed(() => canUseApiPermission(\"subject_aes:list\"));");
+    expect(source).toContain("const canListPd = computed(() => canUseApiPermission(\"subject_pds:list\"));");
+  });
 });

frontend/src/views/subjects/SubjectDetail.vue

@@ -10,7 +10,7 @@
           v-if="subjectEditing"
           type="primary"
           :loading="subjectSaving"
-          :disabled="isReadOnly"
+          :disabled="isReadOnly || !canUpdateSubject"
           @click="saveSubjectEdit"
         >
           {{ TEXT.common.actions.save }}
@@ -18,7 +18,7 @@
         <el-button v-if="subjectEditing" :disabled="isReadOnly" @click="cancelSubjectEdit">
           {{ TEXT.common.actions.cancel }}
         </el-button>
-        <el-button v-else type="primary" :disabled="isReadOnly" @click="startSubjectEdit">
+        <el-button v-else-if="canUpdateSubject" type="primary" :disabled="isReadOnly" @click="startSubjectEdit">
           {{ TEXT.common.actions.edit }}
         </el-button>
         <el-button @click="goBack">{{ TEXT.common.actions.back }}</el-button>
@@ -91,10 +91,22 @@
 
     <el-card class="unified-shell subject-shell subject-tabs-shell">
       <div class="subject-tabs-action">
-        <el-button type="primary" :loading="currentTabAction.loading" :disabled="isReadOnly" @click="currentTabAction.onClick">
+        <el-button
+          v-if="currentTabAction.allowed"
+          type="primary"
+          :loading="currentTabAction.loading"
+          :disabled="isReadOnly"
+          @click="currentTabAction.onClick"
+        >
           {{ currentTabAction.label }}
         </el-button>
-        <el-button v-if="activeTab === 'visits'" type="warning" plain :disabled="isReadOnly" @click="openEarlyTerminationDialog">
+        <el-button
+          v-if="activeTab === 'visits' && canCreateVisit"
+          type="warning"
+          plain
+          :disabled="isReadOnly"
+          @click="openEarlyTerminationDialog"
+        >
           提前终止
         </el-button>
         <el-button v-if="adherenceEditing && activeTab === 'medicationAdherence'" :disabled="isReadOnly" @click="adherenceEditing = false">
@@ -108,9 +120,10 @@
               <template #default="scope">{{ displayDate(scope.row.record_date) }}</template>
             </el-table-column>
             <el-table-column prop="content" :label="TEXT.common.fields.content" show-overflow-tooltip />
-            <el-table-column :label="TEXT.common.labels.actions" width="140">
+            <el-table-column v-if="canUpdateHistory || canDeleteHistory" :label="TEXT.common.labels.actions" width="140">
               <template #default="scope">
                 <el-button
+                  v-if="canUpdateHistory"
                   link
                   type="primary"
                   size="small"
@@ -120,6 +133,7 @@
                   {{ TEXT.common.actions.edit }}
                 </el-button>
                 <el-button
+                  v-if="canDeleteHistory"
                   link
                   type="danger"
                   size="small"
@@ -183,10 +197,10 @@
                 <span v-else>{{ scope.row.notes || TEXT.common.fallback }}</span>
               </template>
             </el-table-column>
-            <el-table-column :label="TEXT.common.labels.actions" width="140">
+            <el-table-column v-if="canUpdateVisit || canDeleteVisit" :label="TEXT.common.labels.actions" width="140">
               <template #default="scope">
                 <template v-if="visitEditingRowId === scope.row.id">
-                  <el-button link type="primary" size="small" :disabled="isReadOnly" @click="saveVisitRow(scope.row)">
+                  <el-button v-if="canUpdateVisit" link type="primary" size="small" :disabled="isReadOnly" @click="saveVisitRow(scope.row)">
                     {{ TEXT.common.actions.save }}
                   </el-button>
                   <el-button link size="small" :disabled="isReadOnly" @click="cancelVisitRow">
@@ -195,6 +209,7 @@
                 </template>
                 <template v-else>
                   <el-button
+                    v-if="canUpdateVisit"
                     link
                     type="primary"
                     size="small"
@@ -204,6 +219,7 @@
                     {{ TEXT.common.actions.edit }}
                   </el-button>
                   <el-button
+                    v-if="canDeleteVisit"
                     link
                     type="danger"
                     size="small"
@@ -244,7 +260,7 @@
                   :controls="false"
                   size="small"
                   class="adherence-count-input"
-                  :disabled="isReadOnly"
+                  :disabled="isReadOnly || !canUpdateSubject"
                 />
                 <span v-else>{{ actualMedicationCountText }}</span>
               </el-descriptions-item>
@@ -283,9 +299,10 @@
               <template #default="scope">{{ displayText(scope.row.outcome, TEXT.enums.aeOutcome) }}</template>
             </el-table-column>
             <el-table-column prop="description" :label="TEXT.common.fields.remark" show-overflow-tooltip />
-            <el-table-column :label="TEXT.common.labels.actions" width="140">
+            <el-table-column v-if="canUpdateAe || canDeleteAe" :label="TEXT.common.labels.actions" width="140">
               <template #default="scope">
                 <el-button
+                  v-if="canUpdateAe"
                   link
                   type="primary"
                   size="small"
@@ -295,6 +312,7 @@
                   {{ TEXT.common.actions.edit }}
                 </el-button>
                 <el-button
+                  v-if="canDeleteAe"
                   link
                   type="danger"
                   size="small"
@@ -324,9 +342,10 @@
             <el-table-column prop="status" :label="TEXT.common.fields.status">
               <template #default="scope">{{ displayEnum(TEXT.enums.pdStatus, scope.row.status) }}</template>
             </el-table-column>
-            <el-table-column :label="TEXT.common.labels.actions" width="140">
+            <el-table-column v-if="canUpdatePd || canDeletePd" :label="TEXT.common.labels.actions" width="140">
               <template #default="scope">
                 <el-button
+                  v-if="canUpdatePd"
                   link
                   type="primary"
                   size="small"
@@ -336,6 +355,7 @@
                   {{ TEXT.common.actions.edit }}
                 </el-button>
                 <el-button
+                  v-if="canDeletePd"
                   link
                   type="danger"
                   size="small"
@@ -365,7 +385,7 @@
       </el-form>
       <template #footer>
         <el-button @click="historyDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-        <el-button type="primary" :disabled="isReadOnly" @click="saveHistory">{{ TEXT.common.actions.save }}</el-button>
+        <el-button type="primary" :disabled="isReadOnly || !canSaveHistory" @click="saveHistory">{{ TEXT.common.actions.save }}</el-button>
       </template>
     </el-dialog>
 
@@ -396,7 +416,7 @@
       </el-form>
       <template #footer>
         <el-button @click="visitDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-        <el-button type="primary" :disabled="isReadOnly" @click="saveVisit">{{ TEXT.common.actions.save }}</el-button>
+        <el-button type="primary" :disabled="isReadOnly || !canSaveVisit" @click="saveVisit">{{ TEXT.common.actions.save }}</el-button>
       </template>
     </el-dialog>
 
@@ -423,7 +443,7 @@
       </div>
       <template #footer>
         <el-button @click="earlyTerminationDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-        <el-button type="primary" :loading="earlyTerminationSaving" :disabled="isReadOnly" @click="saveEarlyTermination">
+        <el-button type="primary" :loading="earlyTerminationSaving" :disabled="isReadOnly || !canCreateVisit" @click="saveEarlyTermination">
           {{ TEXT.common.actions.save }}
         </el-button>
       </template>
@@ -464,7 +484,7 @@
       </el-form>
       <template #footer>
         <el-button @click="aeDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-        <el-button type="primary" :disabled="isReadOnly" @click="saveAe">{{ TEXT.common.actions.save }}</el-button>
+        <el-button type="primary" :disabled="isReadOnly || !canSaveAe" @click="saveAe">{{ TEXT.common.actions.save }}</el-button>
       </template>
     </el-dialog>
 
@@ -494,7 +514,7 @@
       </el-form>
       <template #footer>
         <el-button @click="pdDialogVisible = false">{{ TEXT.common.actions.cancel }}</el-button>
-        <el-button type="primary" :disabled="isReadOnly" @click="savePd">{{ TEXT.common.actions.save }}</el-button>
+        <el-button type="primary" :disabled="isReadOnly || !canSavePd" @click="savePd">{{ TEXT.common.actions.save }}</el-button>
       </template>
     </el-dialog>
   </div>
@@ -504,6 +524,7 @@
 import { computed, onMounted, reactive, ref, watch } from "vue";
 import { useRoute, useRouter } from "vue-router";
 import { ElMessage, ElMessageBox } from "element-plus";
+import { useAuthStore } from "../../store/auth";
 import { useStudyStore } from "../../store/study";
 import { getSubject, updateSubject } from "../../api/subjects";
 import { fetchSites } from "../../api/sites";
@@ -512,13 +533,23 @@ import { fetchVisits, createEarlyTerminationVisit, createVisit, updateVisit, del
 import { fetchAes, createAe, updateAe, deleteAe } from "../../api/aes";
 import { listSubjectPds, createSubjectPd, updateSubjectPd, deleteSubjectPd } from "../../api/subjectPds";
 import { displayDate, displayEnum, displayText } from "../../utils/display";
+import { isApiPermissionAllowed } from "../../utils/apiPermissionValue";
+import { getProjectRole, isSystemAdmin } from "../../utils/roles";
 import { TEXT } from "../../locales";
 
 const route = useRoute();
 const router = useRouter();
+const auth = useAuthStore();
 const study = useStudyStore();
 const subjectId = route.params.subjectId as string;
 const studyId = study.currentStudy?.id || "";
+const projectRole = computed(() => getProjectRole(study.currentStudy, study.currentStudyRole));
+const canUseApiPermission = (operationKey: string) => {
+  if (isSystemAdmin(auth.user)) return true;
+  const role = projectRole.value;
+  if (!role) return false;
+  return isApiPermissionAllowed(study.currentPermissions?.[role]?.[operationKey]);
+};
 const resolveTabFromQuery = () => {
   const tab = typeof route.query.tab === "string" ? route.query.tab : "";
   return ["history", "visits", "medicationAdherence", "ae", "pd"].includes(tab) ? tab : "history";
@@ -552,12 +583,17 @@ const subjectForm = reactive({
 const siteMap = ref<Record<string, string>>({});
 const siteActiveMap = ref<Record<string, boolean>>({});
 const isReadOnly = computed(() => !!detail.site_id && siteActiveMap.value[detail.site_id] === false);
+const canUpdateSubject = computed(() => canUseApiPermission("subjects:update"));
 const activeTab = ref(resolveTabFromQuery());
 
 const historyItems = ref<any[]>([]);
 const loadingHistory = ref(false);
 const historyDialogVisible = ref(false);
 const historyEditingId = ref<string | null>(null);
+const canCreateHistory = computed(() => canUseApiPermission("subject_histories:create"));
+const canUpdateHistory = computed(() => canUseApiPermission("subject_histories:update"));
+const canDeleteHistory = computed(() => canUseApiPermission("subject_histories:delete"));
+const canSaveHistory = computed(() => (historyEditingId.value ? canUpdateHistory.value : canCreateHistory.value));
 const historyForm = reactive({
   record_date: "",
   content: "",
@@ -570,6 +606,10 @@ const earlyTerminationDialogVisible = ref(false);
 const earlyTerminationSaving = ref(false);
 const visitEditingId = ref<string | null>(null);
 const visitEditingRowId = ref<string | null>(null);
+const canCreateVisit = computed(() => canUseApiPermission("visits:create"));
+const canUpdateVisit = computed(() => canUseApiPermission("visits:update"));
+const canDeleteVisit = computed(() => canUseApiPermission("visits:delete"));
+const canSaveVisit = computed(() => (visitEditingId.value ? canUpdateVisit.value : canCreateVisit.value));
 const visitRowDraft = reactive({
   actual_date: "",
   notes: "",
@@ -590,6 +630,7 @@ const earlyTerminationForm = reactive({
 const isFirstVisit = computed(() => visitForm.visit_code === "V1");
 const adherenceEditing = ref(false);
 const adherenceSaving = ref(false);
+const canEditAdherence = computed(() => canUpdateSubject.value);
 const adherenceForm = reactive({
   actual_medication_count: null as number | null,
 });
@@ -598,6 +639,11 @@ const aeItems = ref<any[]>([]);
 const loadingAes = ref(false);
 const aeDialogVisible = ref(false);
 const aeEditingId = ref<string | null>(null);
+const canListAe = computed(() => canUseApiPermission("subject_aes:list"));
+const canCreateAe = computed(() => canUseApiPermission("subject_aes:create"));
+const canUpdateAe = computed(() => canUseApiPermission("subject_aes:update"));
+const canDeleteAe = computed(() => canUseApiPermission("subject_aes:delete"));
+const canSaveAe = computed(() => (aeEditingId.value ? canUpdateAe.value : canCreateAe.value));
 const aeCausalityOptions = [
   { value: "肯定有关", label: TEXT.enums.aeCausality["肯定有关"] },
   { value: "很可能有关", label: TEXT.enums.aeCausality["很可能有关"] },
@@ -636,6 +682,11 @@ const pdItems = ref<any[]>([]);
 const loadingPds = ref(false);
 const pdDialogVisible = ref(false);
 const pdEditingId = ref<string | null>(null);
+const canListPd = computed(() => canUseApiPermission("subject_pds:list"));
+const canCreatePd = computed(() => canUseApiPermission("subject_pds:create"));
+const canUpdatePd = computed(() => canUseApiPermission("subject_pds:update"));
+const canDeletePd = computed(() => canUseApiPermission("subject_pds:delete"));
+const canSavePd = computed(() => (pdEditingId.value ? canUpdatePd.value : canCreatePd.value));
 const pdTypeOptions = ["知情同意", "排除标准", "药物使用", "入排标准", "访视流程", "检验检查", "其他"];
 const pdLevelOptions = Object.entries(TEXT.enums.pdLevel).map(([value, label]) => ({ value, label }));
 const pdStatusOptions = Object.entries(TEXT.enums.pdStatus).map(([value, label]) => ({ value, label }));
@@ -717,6 +768,10 @@ const startSubjectEdit = () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canUpdateSubject.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   subjectForm.screening_date = detail.screening_date || "";
   subjectForm.consent_date = detail.consent_date || "";
   subjectForm.enrollment_date = detail.enrollment_date || "";
@@ -735,6 +790,10 @@ const saveSubjectEdit = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canUpdateSubject.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   subjectSaving.value = true;
   try {
@@ -776,6 +835,11 @@ const openHistoryDialog = (row?: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  const allowed = row?.id ? canUpdateHistory.value : canCreateHistory.value;
+  if (!allowed) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   historyEditingId.value = row?.id || null;
   historyForm.record_date = row?.record_date || "";
   historyForm.content = row?.content || "";
@@ -787,6 +851,10 @@ const saveHistory = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canSaveHistory.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   try {
     const payload = {
@@ -811,6 +879,10 @@ const removeHistory = async (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canDeleteHistory.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   const ok = await ElMessageBox.confirm(TEXT.common.confirm.delete, TEXT.common.labels.tips).catch(() => null);
   if (!ok) return;
@@ -856,6 +928,11 @@ const openVisitDialog = (row?: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  const allowed = row?.id ? canUpdateVisit.value : canCreateVisit.value;
+  if (!allowed) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   visitEditingId.value = row?.id || null;
   if (row) {
     visitForm.actual_date = row.actual_date || "";
@@ -876,6 +953,10 @@ const openEarlyTerminationDialog = () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canCreateVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   earlyTerminationForm.termination_date = "";
   earlyTerminationForm.reason = "";
   earlyTerminationForm.notes = "";
@@ -887,6 +968,10 @@ const startVisitRowEdit = (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canUpdateVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   visitEditingRowId.value = row?.id || null;
   visitRowDraft.actual_date = row?.actual_date || "";
   visitRowDraft.notes = row?.notes || "";
@@ -901,6 +986,10 @@ const saveVisitRow = async (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canUpdateVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId || !row?.id) return;
   try {
     const payload = {
@@ -1072,6 +1161,10 @@ const saveVisit = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canSaveVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   try {
     if (visitEditingId.value) {
@@ -1106,6 +1199,10 @@ const saveEarlyTermination = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canCreateVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   if (!earlyTerminationForm.termination_date) {
     ElMessage.error("请填写提前终止日期");
@@ -1146,6 +1243,10 @@ const removeVisit = async (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canDeleteVisit.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   const ok = await ElMessageBox.confirm(TEXT.common.confirm.delete, TEXT.common.labels.tips).catch(() => null);
   if (!ok) return;
@@ -1159,6 +1260,10 @@ const removeVisit = async (row: any) => {
 
 const loadAes = async () => {
   if (!studyId || !subjectId) return;
+  if (!canListAe.value) {
+    aeItems.value = [];
+    return;
+  }
   loadingAes.value = true;
   try {
     const { data } = (await fetchAes(studyId, { subject_id: subjectId })) as any;
@@ -1175,6 +1280,11 @@ const openAeDialog = (row?: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  const allowed = row?.id ? canUpdateAe.value : canCreateAe.value;
+  if (!allowed) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   aeEditingId.value = row?.id || null;
   Object.assign(aeForm, {
     term: row?.term || "",
@@ -1194,6 +1304,10 @@ const saveAe = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canSaveAe.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   try {
     const payload = {
@@ -1225,6 +1339,10 @@ const removeAe = async (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canDeleteAe.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId) return;
   const ok = await ElMessageBox.confirm(TEXT.common.confirm.delete, TEXT.common.labels.tips).catch(() => null);
   if (!ok) return;
@@ -1238,6 +1356,10 @@ const removeAe = async (row: any) => {
 
 const loadPds = async () => {
   if (!studyId || !subjectId) return;
+  if (!canListPd.value) {
+    pdItems.value = [];
+    return;
+  }
   loadingPds.value = true;
   try {
     const { data } = (await listSubjectPds(studyId, subjectId)) as any;
@@ -1262,6 +1384,11 @@ const openPdDialog = (row?: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  const allowed = row?.id ? canUpdatePd.value : canCreatePd.value;
+  if (!allowed) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   pdEditingId.value = row?.id || null;
   Object.assign(pdForm, {
     pd_no: row?.pd_no || "",
@@ -1276,19 +1403,19 @@ const openPdDialog = (row?: any) => {
 const currentTabAction = computed(() => {
   switch (activeTab.value) {
     case "visits":
-      return { label: TEXT.common.actions.newVisit, onClick: () => openVisitDialog() };
+      return { label: TEXT.common.actions.newVisit, loading: false, allowed: canCreateVisit.value, onClick: () => openVisitDialog() };
     case "medicationAdherence":
       if (adherenceEditing.value) {
-        return { label: "保存用药次数", loading: adherenceSaving.value, onClick: () => saveMedicationAdherence() };
+        return { label: "保存用药次数", loading: adherenceSaving.value, allowed: canEditAdherence.value, onClick: () => saveMedicationAdherence() };
       }
-      return { label: "编辑", loading: false, onClick: () => startMedicationAdherenceEdit() };
+      return { label: "编辑", loading: false, allowed: canEditAdherence.value, onClick: () => startMedicationAdherenceEdit() };
     case "ae":
-      return { label: TEXT.common.actions.newAe, onClick: () => openAeDialog() };
+      return { label: TEXT.common.actions.newAe, loading: false, allowed: canCreateAe.value, onClick: () => openAeDialog() };
     case "pd":
-      return { label: TEXT.modules.subjectDetail.newPd, onClick: () => openPdDialog() };
+      return { label: TEXT.modules.subjectDetail.newPd, loading: false, allowed: canCreatePd.value, onClick: () => openPdDialog() };
     case "history":
     default:
-      return { label: TEXT.common.actions.newHistory, onClick: () => openHistoryDialog() };
+      return { label: TEXT.common.actions.newHistory, loading: false, allowed: canCreateHistory.value, onClick: () => openHistoryDialog() };
   }
 });
 
@@ -1297,6 +1424,10 @@ const startMedicationAdherenceEdit = () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canEditAdherence.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   adherenceForm.actual_medication_count = detail.actual_medication_count ?? null;
   adherenceEditing.value = true;
 };
@@ -1306,6 +1437,10 @@ const saveMedicationAdherence = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canEditAdherence.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   adherenceSaving.value = true;
   try {
@@ -1327,6 +1462,10 @@ const savePd = async () => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canSavePd.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   if (!pdForm.pd_type?.trim()) {
     ElMessage.error(TEXT.common.messages.required);
@@ -1356,6 +1495,10 @@ const removePd = async (row: any) => {
     ElMessage.warning("中心已停用");
     return;
   }
+  if (!canDeletePd.value) {
+    ElMessage.warning(TEXT.common.messages.noPermission);
+    return;
+  }
   if (!studyId || !subjectId) return;
   const ok = await ElMessageBox.confirm(TEXT.common.confirm.delete, TEXT.common.labels.tips).catch(() => null);
   if (!ok) return;